We compare CryoSPIRE with other methods on three synthetic dataset from CryoBench, a recent standardized benchmark for heterogeneous reconstruction. Two datasets of IgG-1D and IgG-RL are based on the human immunoglobulin G (IgG) complex, simulating conformational heterogeneity of the fragment anti-body. The third dataset, Ribosembly, consists of compositional heterogeneity of Ribosome.